FDA product approval
not established. No approval for this exact marketed preparation or claimed wellness indication is established in this source set.
Research compound · compound · checked 2026-10-09
PE-22-28
PE-22-28 is listed here as a compound. Short spadin-derived peptide examined as a TREK-1 channel inhibitor. Status was checked 2026-10-09. This card reports cited facts. It does not tell you to use PE-22-28 or how much to take.
Last checked Oct 9, 2026 by PepBear. Not medical advice.
- FDA product
- not established
- Compounding
- not established
- Research
- investigational
- Sport
- unknown
What is PE-22-28?
Other names in the library: PE 22 28, spadin analogue, PE-22-28 Spray — 20mg / Non-Lyophilized, PE-22-28 Spray — 20mg / Premium (Out of stock). Evidence describes the named substance, not a quality certification or equivalence assessment of commercial stock. Listed sizes: 20 mg. A seller title is a listing. It does not prove the vial matches a paper.
Short spadin-derived peptide examined as a TREK-1 channel inhibitor.
Regulatory status, dated 2026-10-09
Compounding
not established. Legal compounding eligibility is not established here. Sale or a supplement label does not establish eligibility.
Research
investigational. Cell electrophysiology assays and mouse behavioral models.
Sport
unknown. Not individually verified against current sport rules. Check the exact ingredients with your sport authority.
What the cited papers actually measured
We mark the cited papers as D for Cell electrophysiology assays and mouse behavioral models. and The peptide inhibited TREK-1 in laboratory assays and affected mouse behavioral endpoints.. Mouse behavioral tests do not establish an antidepressant treatment, human benefit or long-term safety. The peptide inhibited TREK-1 in laboratory assays and affected mouse behavioral endpoints. Mouse behavioral tests do not establish an antidepressant treatment, human benefit or long-term safety. Risks on the record: Human safety for this exact preparation is incompletely characterized. A lack of reported problems does not establish safety.
We mark the cited papers as D. That is our label for how strong those papers are. It does not say the compound works.
preclinical
The peptide inhibited TREK-1 in laboratory assays and affected mouse behavioral endpoints.
Cell electrophysiology assays and mouse behavioral models. Mouse behavioral tests do not establish an antidepressant treatment, human benefit or long-term safety.
How long it lasts, how you store it, listed sizes
The catalog does not record a single hour value. No verified human estimate for this exact preparation is supplied. A half-life is not a treatment schedule.
Half-life on file: no single hour value. No verified human estimate for this exact preparation is supplied. A half-life is not a treatment schedule. Follow the label on the vial you hold. This page does not set a throw-away date after you add water.
U-100 math for listed PE-22-28 sizes. Each cell is micrograms per syringe mark if you add that much liquid. The table does the same math as the calculator. It does not pick an amount for you.
| Listed vial | 1 mL liquid | 2 mL liquid | 3 mL liquid |
|---|---|---|---|
| 20 mg | 200 | 100 | 66.7 |
Risks and mix-ups already on the record
- Human safety for this exact preparation is incompletely characterized. A lack of reported problems does not establish safety.
- No complete contraindication list is established for this exact preparation. Review pregnancy, allergies and existing conditions with a clinician.
- No complete interaction study for this exact preparation is verified. Ingredient combinations are not presumed compatible.
People using PepBear often log: Exact product identity, formulation, dated label and any clinician-directed observations. Record symptoms and changes alongside other medicines, sleep and activity; observations do not establish causation.
Sources
- PE-22-28 primary study · PMID 28955242 · checked 2026-10-09
Questions people ask
Is PE-22-28 FDA-approved?
not established. No approval for this exact marketed preparation or claimed wellness indication is established in this source set.
Does PepBear pick an amount of PE-22-28?
The calculator turns numbers you type into U-100 units. Trial or label amounts stay as cited facts.
Related cards
Discuss the evidence and unresolved identity or safety questions with a licensed clinician. This entry provides no treatment instructions. Not medical advice. PepBear does not pick a dose, a cycle, or a seller.